Pittcon 2021 – From Petroleum to Cannabis – Multidimensional Chromatography Solutions for Complex Sample Analysis

Multidimensional Gas Chromotagraphy

Michelle Misselwitz, of Chemistry Matters, will teach a full-day, beginner short-course focused on Multidimensional Gas Chromatography- Mass Spectrometry at Pittcon 2021.  One-dimensional GC analysis of petroleum, cannabis, food, environmental, and biological samples results in numerous overlapping peaks. It is often difficult to achieve fundamental knowledge about a sample, explore impurities, or identify indicative biomarkers without further separation. Comprehensive two-dimensional gas chromatography (GC×GC) has proven successful when 1D-GC is insufficient. This course, taught by a diverse collaboration of scientists, will address the common questions and hesitations about adopting GC×GC. After completion, attendees will be able to compare and contrast different GC×GC systems, identify resources for method development, and formulate strategies for processing GC×GC data.


  1. Introduction
    1. Benefits of GC×GC compared to 1D GC
    2. Fundamentals of GC×GC
    3. History, key papers and references
  2. Applications of GC×GC
    1. Petroleum
    2. Environmental
    3. Forensics
    4. Food Safety
    5. Cannabis
  3. Method Development
    1. Column selection
    2. Temperature and flow parameters
    3. Detector options and requirements
    4. Modulator types and considerations
  4. Hands-on Demonstrations
    1. On-site GC×GC instrument
    2. Column connections and installation
    3. Online resources
  5. Data Analysis
    1. System requirements and options
    2. Data processing parameters
    3. Data reduction strategies
    4. Quantitative and Qualitative analysis
    5. Statistical approaches

The course will target basic users of gas chromatography who are interested in learning about GC×GC. This also includes users who are looking to improve their analysis with an optimized GC×GC approach. Possible attendees include students, researchers, industry scientists, and chemical laboratory technologists.

Chemistry Matters, a niche consulting company, specializes in using GC×GC for industrial clients and forensic investigations. Previously, Michelle developed GC×GC solutions to support the environmental, food safety, petroleum, and botanical markets. Michelle has taught over 15 professional seminars and hands-on courses on the subjects of gas chromatography (GC), mass spectrometry (MS) and sample preparation. She has 10 years of experience with GC×GC, including 5 years of daily operation.  Through education efforts and promoting tangible benefits, Michelle is passionate about increasing widespread adoption of GC×GC.

For more information about Pittcon 2021, click here.