Pentachlorophenol and Hydroxylated Polychlorinated Biphenyl Metabolites in Umbilical Cord Plasma of Neonates from Coastal Populations in Québec.

Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is high because of marine-food-based diets–Nunavik (Inuit people) and the…

Identification of 4-Hydroxyheptachlorostyrene in Polar Bear Plasma and Its Binding Affinity to Transthyretin:  A Metabolite of Octachlorostyrene?

Centre for Analytical and Environmental Chemistry, Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada, Department of Toxicology, Wageningen Agricultural University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands, Wellington Laboratories Inc., 398 Laird Road, Guelph, Ontario, N1G 3X7 Canada, Research Institute of Toxicology, Utrecht University,…

Analysis of Hydroxylated Metabolites of PCBs (OH-PCBs) and Other Chlorinated Phenolic Compounds in Whole Blood from Canadian Inuit.

In this study, we identified the main hydroxylated polychlorinated biphenyls (OH-PCBs) and other chlorinated phenolic compounds and we determined their relative concentrations in whole blood from 13 male and 17 female Inuit from northern Quebec, Canada, and from a pooled whole blood sample from southern Quebec. We also determined concentrations…

The Enantioselective Bioaccumulation of Chiral Chlordane and α-HCH Contaminants in the Polar Bear Food Chain

The enantiomer ratios (ERs) of α-HCH and chlordane related compounds (CHLs) were examined in the polar bear food chain (arctic cod−ringed seal−polar bear), using chiral gas chromatography−mass spectrometry (GC-MS). The cod showed near-racemic mixtures (ER = 1) for most of the compounds. In contrast, ERs in ringed seal and polar…